Regulatory & Safety Clarification

NanoBase™ is not classified as a cosmetic nanomaterial under current FDA, EU, or ISO cosmetic definitions. The platform does not utilize insoluble or persistent nanoparticles, nor does it employ intentionally manufactured nanomaterials under 120 nm requiring nano-labeling. Delivery performance is achieved through 125 nm - 195 nm organized nanostructured domains that enhance penetration, stability, and bioavailability, while remaining fully compliant with cosmetic regulatory frameworks and not classified as regulated nanomaterials.

NanoBase™

NanoBase™ is supported by a publicly archived technical document detailing nanoscale architecture, tri-domain delivery integration, and dynamic light scattering validation under controlled production conditions.

DOI: https://doi.org/10.5281/zenodo.18616576

The Modern Nanodelivery Platform for Performance-Driven Skincare

NanoBase™ is a modular nanodelivery platform engineered at ~165 nm by design, with a Polydispersity Index below 0.20, verified by Dynamic Light Scattering under controlled production conditions.

It replaces legacy HLB emulsification logic with a tri-domain nanoscale architecture engineered for ingredient performance at the skin interface, not just stability in the jar.

At its core, NanoBase™ functions as a structured lipid matrix integrating nanoemulsion, nanoliposomal, and nanomicellar domains into one coordinated system.

Why NanoBase™ Exists

Traditional HLB emulsions were designed to prevent separation.

They were not designed to optimize cosmetic deposition.

Modern actives have evolved. Delivery architecture must evolve with them.

NanoBase™ shifts formulation logic from surfactant balancing to nanoscale structural engineering, improving dispersion uniformity and performance predictability across diverse payloads.

The NanoBase™ Standard

  • Designed mean particle size: ~165 nm

  • Polydispersity Index: <0.20

  • Verification method: Dynamic Light Scattering, intensity-weighted Z-average

  • Architecture: Tri-domain nanoscale matrix

  • Functional objective: Improved cosmetic ingredient distribution and retention at the skin interface

  • Regulatory positioning: Cosmetic delivery platform

The Tri-Domain Architecture

NanoBase™ integrates three nanoscale domains into a unified matrix:

  • Nanoemulsion domain for structural lipid dispersion

  • Nanoliposomal domain for phospholipid-supported organization

  • Nanomicellar domain for stabilization and compatibility support

Instead of suspending actives statistically, NanoBase™ supports them structurally.

This reduces internal formulation conflict and increases dispersion consistency across oil-soluble, water-soluble, and hybrid systems.

What This Means for Brands

  • More consistent cosmetic performance

  • Better structural support for complex active systems

  • Higher predictability across different skin types

  • Modern architectural replacement for legacy HLB foundations

  • Scalable platform compatibility across serum, cream, and hybrid formats

NanoBase™ is not a trend-driven encapsulation gimmick.

It is an architectural upgrade.

Regulatory and Safety Positioning

NanoBase™ is a lipid-based cosmetic delivery platform built from skin-compatible components and engineered at nanoscale dimensions to improve ingredient distribution and retention.

It is positioned strictly for cosmetic applications and does not alter regulatory classification.

NanoBase™ is not positioned as an insoluble engineered nanomaterial. It is a biomimetic lipid matrix measured at nanoscale dimensions.

New Industry Standard

HLB solved shelf stability.

NanoBase™ solves bioavailability delivery architecture.

Ingredients matter. Architecture decides whether they perform.

Want Help Choosing the Right NanoBase™ Delivery System?
What type of product are you creating?
What type of topical nano delivery formula are you creating?
Do you want liposomal delivery or high-load performance?
What kind of leave-on mask is it?
NanoBase™ Sublingual
Specially formulated for consumable products with enhanced bioavailability and rapid absorption for sublingual delivery systems.
NanoBase™ Classic
Best for fluid serums with nano delivery, especially peptides and actives in clear or lightweight formats.
NanoBase™ Classic
Ideal for wash-off masks with nano delivery, providing excellent active penetration during treatment time with clean rinse-off properties.
NanoBase™ LUXE
Best for liposomal nano delivery and daily moisturizers.
NanoBase™ Cleanse
Best for thicker creams, night treatments, or clinical formulations.
NanoBase™ LUXE
Ideal for liposomal moisturizing masks with deep hydration and barrier support.
NanoBase™ Cleanse
Perfect for clinical repair masks requiring enhanced active delivery and barrier support.
NanoBase™ Cleanse
Cleanse is optimized for nano delivery in low-viscosity, rinse-off cleansers and enzyme washes.
Let us help!
Our team can help you choose the right NanoBase™ for your specific formulation needs.
Custom Solution Needed
Your formulation may require a custom approach. Our team can help design the perfect NanoBase™ for your specific needs.
Single Ingredient Nano Dispersion
Want to see what's possible when we apply our nanotechnology to your ingredients?

Whether you use one of our NanoBase™ Delivery Systems, a Custom Delivery System, or prefer your existing traditional system, we can transform raw actives into nano dispersions with unmatched stability and absorption.
What type of nano ingredient are you interested in?
Which type of active ingredient are you looking for?
What type of botanical material are you interested in?
Which lipid system are you interested in?
What type of pigment or effect are you looking for?
Nano Peptide Technology
Our nanotechnology creates sub-200nm peptide complexes that penetrate deeper into the skin's layers, dramatically enhancing bioavailability where conventional peptides cannot reach. This translates to more potent anti-aging and skin repair effects at lower concentrations.
Contact Our Lab
Nano Vitamin Delivery
We transform vitamins A, C, E and others into stable nano-emulsions under 200nm, allowing them to bypass surface barriers and deliver their benefits to deeper skin layers. This advanced delivery system increases efficacy while reducing the irritation potential of active vitamins.
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Nano Antioxidant Systems
Our nano-processing technology creates antioxidant complexes that reach deeper skin layers where free radical damage occurs. By delivering protection beyond the surface, these systems provide superior defense against oxidative stress and environmental aggressors at the cellular level.
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Custom Nano Active Development
We can develop custom nano-active ingredients that transcend the skin's natural barriers, delivering functional benefits to targeted skin layers. Our advanced sonication technology ensures your actives work where they matter most, not just on the surface.
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Nano Botanical Extracts
Our technology transforms plant extracts into nano-suspensions that penetrate beyond the skin's surface where traditional botanicals remain. This deeper delivery ensures active compounds reach their target sites within the skin, maximizing efficacy while maintaining the natural benefits of botanical ingredients.
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Nano Essential Oil Complexes
We create nano-emulsified essential oils that transport active compounds to deeper skin strata rather than sitting on the surface. This advanced delivery not only enhances therapeutic benefits but also improves stability, reduces irritation potential, and creates a more refined sensory experience.
Contact Our Lab
Custom Nano Botanical Development
Our lab can develop custom nano-botanical systems that overcome the limited bioavailability of traditional plant extracts. By reducing particle size to sub-200nm, we ensure your botanical actives traverse the skin's barrier to deliver their benefits where conventional extracts cannot reach.
Contact Our Lab
Nano Ceramide Complexes
Our nanotechnology creates nano-ceramide systems that integrate more effectively into the skin's intercellular matrix. Unlike conventional ceramides that struggle to penetrate, our sub-200nm particles deliver these essential lipids to deeper epidermal layers where they reinforce barrier function from within.
Contact Our Lab
Nano Phospholipid Systems
We create advanced nano phospholipid delivery systems that transport active ingredients through multiple skin layers. These biomimetic carriers facilitate deeper ingredient absorption while simultaneously supporting the skin's natural barrier, creating a dual-action approach to skin health.
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Custom Nano Lipid Development
Our lab can develop custom nano-lipid systems that overcome the penetration limitations of traditional lipid ingredients. By engineering sub-200nm structures, we ensure your lipid actives can traverse skin barriers to deliver their functional benefits at deeper levels where they're most effective.
Contact Our Lab
Nano Mineral Pigment Dispersions
Our technology creates ultra-fine mineral pigment dispersions that integrate more seamlessly with skin. Unlike conventional pigments that sit visibly on the surface, our nano-sized particles create a more natural appearance while maintaining better adhesion and wear properties throughout the day.
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Nano Optical Effect Systems
We create nano-sized optical effect materials that interact with light at multiple skin depths rather than just the surface. This multi-dimensional approach creates more sophisticated light-diffusing, soft-focus, and illuminating properties that appear to emanate from within the skin for a truly natural glow.
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Custom Nano Pigment Development
Our lab can develop custom nano-pigment systems that achieve effects impossible with conventional particle sizes. By engineering sub-200nm pigment structures, we can create unique optical properties and improved skin integration for more sophisticated visual effects that appear to come from within the skin.
Contact Our Lab
Custom Nano Development
Our nanotechnology can create a wide range of sub-200nm materials engineered to penetrate beyond the skin's surface barriers. This advanced delivery capability opens up possibilities for enhanced ingredient performance across multiple cosmetic applications. Tell us about your specific needs, and our lab team will explore custom solutions for your project.
Contact Our Lab

Custom NanoDelivery Platforms

Some projects require a delivery system that doesn't exist yet. For brands who need more than our pre-engineered NanoBase™ platforms, we design fully bespoke NanoDelivery platform from the ground up & fully modular, so you can use any manufacture. Our nano delivery platforms create the most bioavailable form of delivery for beauty products available on the market, all in the fraction of time and cost, all while transforming how actives reach and perform at their target sites.

Every aspect: structure, particle size, compatibility, and stability can be tuned to meet the exact needs of your specific formulation or universal to your entire line.

What Makes a Custom System Different

Built for your actives: Engineered around the unique chemistry of your chosen ingredients for maximum bioavailability.

Tailored particle size: Adjustable nano ranges (typically 80–300 nm) for optimized penetration and release that conventional systems cannot achieve.

Expanded compatibility: Options for non-phospholipid or hybrid structures to handle pigments, peptides, and complex blends at nanoscale.

Revolutionary sublingual delivery: Now offering skin care from the inside out - delivering actives systemically through sublingual absorption for effects that topical applications can't achieve.

Flexible formats: Stable in serums, creams, masks, sublingual applications, or multi-phase systems while maintaining superior nano bioavailability.

Refined feel: Sensory profile designed to match your brand's target texture, from silky serums to luxurious creams.

Use Case Examples

Sublingual beauty systems - the first of their kind for systemic skin benefits without injections

Internal delivery of collagen peptides, antioxidants, and skin-supporting compounds with unprecedented absorption

Advanced treatment serums with high-active loads and maximum bioavailability

Specialty cosmetics needing pigment or optical effect dispersion at nanoscale

Research-driven projects exploring novel nano delivery chemistries

Formulas that combine both hydrophilic and lipophilic agents with enhanced bioavailability

Technical Parameters (Baseline Options)

Fully modular

Shear stability: up to 12,000 rpm

pH stability range: typically 5.0–6.0 (adjustable for custom needs and sublingual compatibility)

Compatible with: peptides, niacinamide, antioxidants, botanical extracts, pigment dispersions & more

Not recommended for: heavily wax-based systems or solvent-heavy alcohol formulations

NanoBase™

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