NanoBase™ · Treatment Architecture
NanoBase™ Clinical.
The treatment-class member of the family. Clinical runs the fully modular Luxe architecture with a co-emulsifier built in for a richer, more cushioned professional texture — while the underlying tri-domain delivery colloid stays engineered at ~185 nm and holds the same electrostatic wall. Bench characterisation places the core colloid at Luxe-equivalent size at the health angle.
Treatment architecture
~55% typical use
Cushioned professional feel
Any CM can build on it
At a glance
~185 nmEngineered mean particle size, DLS-confirmed
pH 5.7–6.0Working window; 5.85 nominal
Luxe-equivalentCore delivery colloid, measured at the bench
~55%Typical use level in the finished cream
How it holds
Same wall. Different sensory brief.
Clinical is not a separate chemistry. It is the Luxe electrostatic platform — the same anionic interfacial wall, the same three domains, the same process and order — with a naturally derived co-emulsifier incorporated during processing to give the finished treatment product a slower, more cushioned break and a more substantive skin feel. The delivery architecture underneath is unchanged, which is the point: you get the professional texture without trading away the colloid.
NE
Nanoemulsion domain
Lipid capacity at Luxe scale. Takes the oil phase you add downstream.
NL
Nanoliposomal domain
Bilayer organisation for peptides and sensitive hydrophilic actives. Intact and confirmed by distribution shape, not just by size.
NM
Nanomicellar reserve
Full Luxe-scale reserve, added cold. The compatibility buffer for what you build on top.
What Clinical is for
✕A rich treatment cream that gets its body from wax and thickener
→
✓Richness from a structured colloid, not from occlusive filler
✕Professional feel bought by sacrificing active delivery
→
✓Core delivery colloid measured Luxe-equivalent at the bench
✕A separate chemistry to qualify, validate and scale
→
✓Same wall, same process, same QC gates as the rest of the platform
✕Heat and high shear to build the finished treatment product
→
✓Cold-processable downstream, like every NanoBase™ architecture
Clinical is the right choice when the brief calls for a substantive, professional-feeling treatment texture and you are not willing to give up the delivery architecture to get it. Like every NanoBase™ architecture, it is fully modular — any contract manufacturer can build the finished product on it.
Specification
What Clinical is built to.
Characterised by multi-angle Dynamic Light Scattering. Distribution shape is judged across angles rather than by a single cumulant, because the co-emulsifier contributes tail breadth that a single number would misread as a defect.
~185 nm
Engineered mean particle size
DLS
Multi-angle, distribution shape assessed
5.85
Nominal pH; working floor 5.7
~55%
Typical use level in a finished cream
Parameter
NanoBase™ Clinical
Notes
Formulation class
Fully modular tri-domain nano-delivery architecture
Treatment class. Luxe architecture plus a built-in co-emulsifier
Stabilisation
Engineered interfacial charge
Identical wall to Classic and Luxe
Sensory position
Cushioned, slower break, more substantive
Versus Luxe's lighter cream feel
Downstream oil load
Supports ~15–18%
Self-partitions; no added surfactant needed
Downstream peptide load
Supports ~5%
Absorbed by the liposomal domain
Water phase
Built in
Never a need for added water in formulation
Processing downstream
Gentle mixing, 22–25 °C
No homogeniser, no sonication, no heat
Shear stability
Up to 12,000 rpm
Headroom for standard production equipment
Preservation
Non-ionic system
Phenoxyethanol level held under the Clean at Sephora cap
Characterisation is performed under controlled production conditions. Figures describe the engineered architecture itself; finished-product performance depends on the formula built on top of it. Clinical is positioned strictly for cosmetic applications and does not alter regulatory classification.
Measured, not asserted
The instrument record.
NanoBase™ is engineered to a platform target of ~185 nm, and every batch is then characterised individually by Dynamic Light Scattering before release. Below is an actual analyser record from a Clinical batch — the raw instrument output, not a redrawn chart.
194.0 nmZ-average for this batch (± 0.52)
0.203Polydispersity index (± 0.002)
UnimodalSingle population across three repeats
90.0°Scattering angle, aqueous diluent at 25 °C
Individual repeats: 194.7 / 193.4 / 194.0 nm. Clinical’s polydispersity index sits marginally above the 0.20 mark, and that is expected rather than a fault: the built-in co-emulsifier contributes tail breadth, so distribution shape is judged across scattering angles rather than by a single cumulant. Read at the health angle, the core tri-domain delivery colloid measures Luxe-equivalent. Full batch documentation is available under NDA for qualified development programmes.
How you use it
Treatment texture, built cold.
01
Start with the architecture
Clinical goes in at roughly 55% of your finished cream. The water phase is built in, so there is never a need to add water.
02
Add your oil phase
Up to about 18% of your own oils and lipophilic actives. Room temperature, no emulsifier, no heat.
03
Add your actives
Around 5% peptide, plus antioxidants, humectants and botanicals. Charge-mapped so cationic actives do not compromise the wall.
04
Let it partition, then fill
Gentle mixing distributes everything into the existing domains. Confirm pH sits at or above 5.7 and fill.
MANUFACTURE ANYWHERE
Any contract manufacturer can build your treatment product on Clinical.
The architecture is fully modular and arrives already built, so your CM never has to make it. No nano equipment, no sonication, no tech transfer, no specialist training — the whole downstream process runs on the room-temperature mixing equipment every contract manufacturer already owns. Bring your own CM or we will introduce you to one. You own the formula and the SDS either way.
Compatibility
What it takes, and what it does not.
Works with
Designed for
- Peptides and peptide complexes
- Antioxidants and vitamin systems
- Botanical extracts and oils
- Humectants and polyol systems
- Mild acids and well-tolerated actives
- Barrier-support lipid blends
Not suited to
Use a different architecture for
- High-alcohol systems
- Heavily wax-based or anhydrous formats
- Formulas requiring added water downstream
- Formulas that must run below pH 5.7
- Lightweight serums — use Classic
Advanced treatment creams
High active loads inside a professional-feeling texture.
Post-procedure support
Substantive, non-greasy feel for compromised-barrier protocols.
Professional back-bar
Treatment-room products where sensory signals efficacy.
Sensitive-ingredient systems
Actives organised into the domain that suits them.
Prestige treatment lines
Clinical positioning without clinical-feeling texture.
Clean-market lines
Non-ionic preservation compatible with clean retailer standards.
Treatment products, on architecture.
Tell us the protocol and the actives. We will show you what it looks like engineered on Clinical.
Questions? team@pensivebeauty.com