NanoBase™ – Clinical Overview for Research and Professional Use

Formulation Class: Phospholipid-based nanoemulsion

Primary Function: Structuring base for topical delivery systems

NanoBase™ is available in two performance formats:

• Classic – high water content (~73%) for lightweight serums and fast-absorbing textures

• LUXE – lower water content (~54%) for rich emulsions and cream-based systems

Custom water-phase ratios are available to tailor viscosity and texture.

Structural Properties:

  • Mean Droplet Size: ~200 nm ± 10 nm

  • Emulsion Type: Colloidal phospholipid nanoemulsion

  • Functional Delivery Behavior: Enhanced topical dispersion and skin contact due to small particle size

⚙️ Technical Foundation

NanoBase™ utilizes phosphatidylcholine-rich phospholipids to create a nanoscale emulsion system. The phospholipid interface supports even ingredient dispersion across the skin surface. Designed for cosmetic formulations that benefit from improved delivery uniformity and elegant feel.

For formulators seeking higher-performance delivery of sensitive actives, NanoBase™ may assist with minimizing oxidation and maximizing ingredient consistency.

Structural Consideration

The design of NanoBase™ draws from established principles in nanoscale phospholipid systems, where vesicular or colloidal droplets enhance topical uniformity and support advanced skin contact characteristics. While not a drug delivery platform, NanoBase™ leverages some of the same physical structuring insights that have been explored in pharmaceutical literature.

🧹 Use Case Examples

  • Professional skincare systems for post-procedure recovery (microneedling, aesthetic facials)

  • Peptide and growth factor serums

  • Brightening systems using niacinamide or retinoid alternatives

  • Cosmetic research projects focused on high-performance delivery

🧪 Formulation Performance Observations

  • May support uniform active dispersion in cream and serum formats

  • Base structure may help reduce visible irritation associated with high concentrations of actives

  • In internal testing, actives suspended in NanoBase™ showed improved formula clarity and sensory profile

🧪 Formulation Performance Observations

• Structural distribution characteristics: Nanoemulsions in the 190 to 210 nm range have been explored in laboratory models for their ability to provide uniform topical dispersion and close skin contact.¹

• Stability of sensitive actives: The phospholipid matrix of NanoBase™ may help maintain the stability of oxidation-prone ingredients such as peptides and antioxidants by limiting exposure to air and light during formulation and storage.

• Gentler-feeling applications: Lower usage levels of potent cosmetic actives can be employed when they are dispersed in NanoBase™, supporting well-tolerated formulas in internal panel assessments.

• Efficient active utilization: Internal tests show that peptides formulated in NanoBase™ can achieve target cosmetic performance at lower inclusion rates compared with conventional emulsions of matched viscosity, depending on peptide structure and overall formula design.

🔬 Formulation Compatibility

  • Stable at shear speeds up to 12,000 rpm

  • pH stability range: 5.0–5.8

  • Compatible with: DMAE, Bakuchiol, Niacinamide, Sodium PCA, EGF, peptides, tocotrienols, etc.

  • Not compatible with: High-alcohol systems or heavily occlusive formulations

NanoBase