NanoBase Classic & Luxe

Clinical Overview for Research and Professional Use

Formulation Class: Phospholipid-based nanoemulsion

Primary Function: Structuring base for topical delivery systems

NanoBase™ Classic & Luxe is available in two performance formats:

• Classic – for lightweight serums and fast-absorbing textures

• LUXE – for rich emulsions and cream-based systems

Custom water-phase ratios are available to tailor viscosity and texture.

Structural Properties:

  • Mean Droplet Size: ~200 nm ± 10 nm

  • Emulsion Type: Colloidal phospholipid nanoemulsion

  • Functional Delivery Behavior: Enhanced topical dispersion and skin contact due to small particle size

⚙️ Technical Foundation

NanoBase™ utilizes phosphatidylcholine-rich phospholipids to create a nanoscale emulsion system. The phospholipid interface supports even ingredient dispersion across the skin surface. Designed for cosmetic formulations that benefit from improved delivery uniformity and elegant feel.

For brands & formulators seeking higher-performance delivery of sensitive actives, NanoBase™ may assist with minimizing oxidation and maximizing ingredient consistency.

Structural Consideration

The design of NanoBase™ draws from established principles in nanoscale phospholipid systems, where vesicular or colloidal droplets enhance topical uniformity and support advanced skin contact characteristics. While not a drug delivery platform, NanoBase™ leverages some of the same physical structuring insights that have been explored in pharmaceutical literature.

🧪 Formulation Performance Observations

• Structural distribution characteristics: Nanoemulsions in the 190 to 210 nm range have been explored in laboratory models for their ability to provide uniform topical dispersion and close skin contact.¹

• Stability of sensitive actives: The phospholipid matrix of NanoBase™ may help maintain the stability of oxidation-prone ingredients such as peptides and antioxidants by limiting exposure to air and light during formulation and storage.

• Gentler-feeling applications: Lower usage levels of potent cosmetic actives can be employed when they are dispersed in NanoBase™, supporting well-tolerated formulas in internal panel assessments.

• Efficient active utilization: Internal tests show that peptides formulated in NanoBase™ can achieve target cosmetic performance at lower inclusion rates compared with conventional emulsions of matched viscosity, depending on peptide structure and overall formula design.

🔬 Formulation Compatibility

  • Stable at shear speeds up to 12,000 rpm

  • pH stability range: 5.0–5.8

  • Compatible with: DMAE, Bakuchiol, Niacinamide, Sodium PCA, EGF, peptides, tocotrienols, etc.

  • Not compatible with: High-alcohol systems or heavily occlusive formulations

🧹 Use Case Examples

  • Professional skincare systems for post-procedure recovery (microneedling, aesthetic facials)

  • Peptide and growth factor serums

  • Brightening systems using niacinamide or retinoid alternatives

  • Cosmetic research projects focused on high-performance delivery

🧪 Formulation Performance Observations

  • May support uniform active dispersion in cream and serum formats

  • Base structure may help reduce visible irritation associated with high concentrations of actives

  • In internal testing, actives suspended in NanoBase™ showed improved formula clarity and sensory profile

NanoBase™ X

Developed for breakthrough formulations where traditional lipid systems may not be the best fit, NanoBase™ X can be offered in custom ultra-fine particle size and exceptional stability with a non-phospholipid structure. This unique approach expands compatibility with advanced actives and visually dynamic cosmetic effects.

🧪 Formulation Performance Observations

  • Structural distribution characteristics: Nanoemulsions in the 80–300 nm range have been explored in laboratory models for their ability to provide deep, smooth, even dispersion of actives.

  • Expanded compatibility: Non-phospholipid structure supports pigment dispersions, optical modifiers, and other specialty effects.

  • Flexible formulation potential: Maintains stability in high-impact serums and complex cream formats.

  • Consistent sensory profile: Demonstrates a refined, non-greasy feel and maintains clarity in internal testing.

🧹 Use Case Examples

  • High-performance treatment serums with unique active combinations

  • Cosmetic research projects involving advanced delivery chemistries

  • Formulas requiring compatibility with both hydrophilic and lipophilic visual effects agents

🔬 Formulation Compatibility

  • Stable at shear speeds up to 12,000 rpm

  • pH stability range: 5.0–6.0

  • Compatible with: Bakuchiol, Niacinamide, peptides, tocotrienols, pigment dispersions, specialty optical modifiers

  • Not compatible with: High-alcohol systems or heavily wax-based formulations