Why Skin Deposition is the Next Frontier in Skincare Globally
The New Standard in Ingredient Performance: The NanoBase™ Architecture
Introduction: The Deposition Gap
In the global skincare market, the conversation has shifted from ingredient lists to performance metrics at the skin interface. Even the most potent cosmetic actives, retinoids, vitamin C derivatives, and peptides, face a significant hurdle: deposition, meaning how much active is retained at the skin interface, and where. Traditional emulsions often lack the structural support needed to keep these actives stable and effectively distributed. NanoBase™ enters the conversation not as a simple base, but as a lipid-based delivery matrix designed to improve stability and skin deposition of cosmetic actives.
Beyond the Basics: The Evolution of Lipid Carriers
To understand why NanoBase™ is necessary, we must look at the documented trade-offs of existing high-performance routes:
• Liposomes: While pioneering, liposomes can face physical and chemical instability. Depending on composition and storage conditions, they are prone to structural changes and payload leakage.
• Solid Lipid Nanoparticles (SLNs): These offer protection for certain actives but are known for active expulsion. As lipids crystallize during storage, they can reduce entrapment of the payload, leading to inconsistent performance over time.
• Nanostructured Lipid Carriers (NLCs): These improved on SLNs by using a less ordered matrix to reduce expulsion risk. However, NLCs can be more demanding to scale consistently, because performance is sensitive to lipid composition, processing conditions, and QC controls.
NanoBase™: A Modern Delivery Architecture
NanoBase™ represents a refined iteration of lipid-carrier technology. We engineered this architecture to prioritize structural robustness and formulation compatibility, allowing labs running modern GMP workflows to achieve high-performance results without the common pitfalls of traditional nanocarriers.
The Three Pillars of NanoBase™ Performance
Reduced Degradation Pathways: NanoBase™ is engineered to reduce common degradation pathways for delicate actives, including oxidative stress and ingredient-to-ingredient interactions within the formula.
Optimized Skin Deposition: By controlling lipid matrix composition, NanoBase™ is engineered to improve how cosmetic actives distribute and retain at the skin interface, particularly within the stratum corneum, with performance dependent on the active and the overall formula design.
Reduced Payload Drift Risk: Unlike some solid-lipid systems where crystallization over time can reduce entrapment, the NanoBase™ architecture is engineered to reduce payload drift risk during shelf life, supporting more consistent performance from manufacture through use.
Engineering for Scale
For the modern founder, “best” now means performance you can measure. We frame NanoBase™ in terms of deposition, retention, and stability metrics assessed with standard lab methods, not marketing adjectives. Common validation routes include tape stripping, confocal Raman spectroscopy, and Franz diffusion cell studies, selected based on the active and the claim boundary. Outcomes vary by active chemistry, dose, and overall formula design.
By integrating a NanoBase™ delivery architecture, qualified contract manufacturers can offer clients a “hero product” built on measurable performance logic, designed for global cosmetic positioning.
