Why Most Skincare Actives Never Reach the Dermis

Conventional emulsions produce 1–100 µm carriers against a stratum corneum barrier with 10–50 nm intercellular spacing — a dimensional mismatch that precludes transepidermal transport. NanoBase™ tri-domain nano-delivery (125–195 nm, PDI ≤0.20) resolves all three HLB barriers simultaneously.